Fluoxetine Improves the Effect of Levodopa on 6-Hydroxy Dopamine-Induced Motor Impairments in Rats

Fluoxetine Improves the Effect of Levodopa on 6-Hydroxy Dopamine-Induced Motor Impairments in Rats

Purpose: Long term L-DOPA therapy in Parkinson’s disease is associated with troublesome motor fluctuations such as L -DOPA Induced dyskinesia and wearing off effect. Our recent study showed that activation of 5-HT1A receptors could improve the anti-cataleptic effect of L-DOPA in parkinsonian rats. I...

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Bibliographic Details
Main Authors: Javad Mahmoudi, Alireza Mohajjel Nayebi, Siyamak Reyhani-Rad, Morteza Samini
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2012-06-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
L-DOPA
Fluoxetine
5-HT1A receptor
Catalepsy
Motor imbalance
Rat
Online Access:http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-2-149.pdf

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