New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species

The combination of liquid chromatography coupled to high resolution mass spectrometry (LC-HRESMS)-based dereplication and antiproliferative activity-guided fractionation was applied on the Red Sea-derived soft coral <i>Sarcophyton</i> sp. This approach facilitated the isolation of five n...

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Main Authors:	Hossam M. Hassan, Mostafa E. Rateb, Marwa H. Hassan, Ahmed M. Sayed, Samah Shabana, Mai Raslan, Elham Amin, Fathy A. Behery, Osama M. Ahmed, Abdullatif Bin Muhsinah, Tobias A. M. Gulder, Usama Ramadan Abdelmohsen
Format:	Article
Language:	English
Published:	MDPI AG 2019-07-01
Series:	Marine Drugs
Subjects:	LCHRESMS dereplication cembranoids <i>Sarcophyton</i> antiproliferative
Online Access:	https://www.mdpi.com/1660-3397/17/7/411

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spelling	doaj-79efe56d9bfc4f798e451fa7823f52532020-11-24T21:29:17ZengMDPI AGMarine Drugs1660-33972019-07-0117741110.3390/md17070411md17070411New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> SpeciesHossam M. Hassan0Mostafa E. Rateb1Marwa H. Hassan2Ahmed M. Sayed3Samah Shabana4Mai Raslan5Elham Amin6Fathy A. Behery7Osama M. Ahmed8Abdullatif Bin Muhsinah9Tobias A. M. Gulder10Usama Ramadan Abdelmohsen11Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, EgyptPharmacognosy Department, College of Pharmaceutical Sciences & Drug Manufacturing, Misr University for Science and Technology (MUST), Six October City 77, EgyptBiotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, EgyptPhysiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, EgyptDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi ArabiaChair of Technical Biochemistry, Department of Chemistry and Food Chemsitry, Technical University of Dresden, Bergestrabe 66, Dresden 01069, GermanyDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, EgyptThe combination of liquid chromatography coupled to high resolution mass spectrometry (LC-HRESMS)-based dereplication and antiproliferative activity-guided fractionation was applied on the Red Sea-derived soft coral <i>Sarcophyton</i> sp. This approach facilitated the isolation of five new cembrane-type diterpenoids (<b>1</b>−<b>5</b>), along with two known analogs (<b>6</b> and <b>7</b>), as well as the identification of 19 further, known compounds. The chemical structures of the new compounds were elucidated while using comprehensive spectroscopic analyses, including one-dimensional (1D) and two-dimensional (2D) NMR and HRMS. All of the isolated cembranoids (<b>1</b>−<b>7</b>) showed moderate <i>in vitro</i> antiproliferative activity against a human breast cancer cell line (MCF-7), with IC<sub>50</sub> ranging from 22.39−27.12 µg/mL. This class of compounds could thus serve as scaffold for the future design of anticancer leads.https://www.mdpi.com/1660-3397/17/7/411LCHRESMSdereplicationcembranoids<i>Sarcophyton</i>antiproliferative
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hossam M. Hassan Mostafa E. Rateb Marwa H. Hassan Ahmed M. Sayed Samah Shabana Mai Raslan Elham Amin Fathy A. Behery Osama M. Ahmed Abdullatif Bin Muhsinah Tobias A. M. Gulder Usama Ramadan Abdelmohsen
spellingShingle	Hossam M. Hassan Mostafa E. Rateb Marwa H. Hassan Ahmed M. Sayed Samah Shabana Mai Raslan Elham Amin Fathy A. Behery Osama M. Ahmed Abdullatif Bin Muhsinah Tobias A. M. Gulder Usama Ramadan Abdelmohsen New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species Marine Drugs LCHRESMS dereplication cembranoids <i>Sarcophyton</i> antiproliferative
author_facet	Hossam M. Hassan Mostafa E. Rateb Marwa H. Hassan Ahmed M. Sayed Samah Shabana Mai Raslan Elham Amin Fathy A. Behery Osama M. Ahmed Abdullatif Bin Muhsinah Tobias A. M. Gulder Usama Ramadan Abdelmohsen
author_sort	Hossam M. Hassan
title	New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species
title_short	New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species
title_full	New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species
title_fullStr	New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species
title_full_unstemmed	New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species
title_sort	new antiproliferative cembrane diterpenes from the red sea <i>sarcophyton</i> species
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2019-07-01
description	The combination of liquid chromatography coupled to high resolution mass spectrometry (LC-HRESMS)-based dereplication and antiproliferative activity-guided fractionation was applied on the Red Sea-derived soft coral <i>Sarcophyton</i> sp. This approach facilitated the isolation of five new cembrane-type diterpenoids (<b>1</b>−<b>5</b>), along with two known analogs (<b>6</b> and <b>7</b>), as well as the identification of 19 further, known compounds. The chemical structures of the new compounds were elucidated while using comprehensive spectroscopic analyses, including one-dimensional (1D) and two-dimensional (2D) NMR and HRMS. All of the isolated cembranoids (<b>1</b>−<b>7</b>) showed moderate <i>in vitro</i> antiproliferative activity against a human breast cancer cell line (MCF-7), with IC<sub>50</sub> ranging from 22.39−27.12 µg/mL. This class of compounds could thus serve as scaffold for the future design of anticancer leads.
topic	LCHRESMS dereplication cembranoids <i>Sarcophyton</i> antiproliferative
url	https://www.mdpi.com/1660-3397/17/7/411
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New Antiproliferative Cembrane Diterpenes from the Red Sea <i>Sarcophyton</i> Species

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