Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State

Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State

Hypercholesterolemia has previously been induced in the mouse by a single intravenous injection of adeno-associated virus (AAV)-based vector harboring gain-of-function pro-protein convertase subtilisin/kexin type 9. Despite the recent emergence of the PCSK9-AAV model, the profile of hematological an...

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Bibliographic Details
Main Authors: Georgios Louloudis, Samuele Ambrosini, Francesco Paneni, Giovanni G. Camici, Dietmar Benke, Jan Klohs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
PCSK9
hypercholesterolemia
mouse
neutrophils
monocytes
coagulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.718741/full

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