Oxidative stress, its role in the pathogenesis of chronic heart failure, and potential methods of correction

• Main Authors: L. O. Palatkina, O. N. Korneeva, O. M. Drapkina
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2012-12-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: reactive oxygen species; oxidative stress; chronic heart failure; pleiotropic effects; statins
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/2039

For many years, cardiovascular disease (CVD) remains the leading cause of death worldwide. According to the World Health Organization estimates, CVD accounts for 57% of all-cause mortality in Russia. Recently, research efforts have been concentrated on the search for new CVD markers which can improve the diagnostics and treatment of this large disease group, associated with poor prognosis. The markers of oxidative stress (OS) and antioxidant enzyme activity have been considered as potential pathogenetic mechanisms in the CVD development. The potential of statins, as medications with a wide range of pleiotropic – in particular, antioxidant – effects, for the effective management of chronic heart failure (CHF) has been extensively investigated. There is an ongoing discussion whether statins could be used for the treatment of nonischemic CHF.