Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma

Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma

Resistance to standard cisplatin‐based chemotherapies leads to worse survival outcomes for patients with esophageal squamous cell carcinoma (ESCC). Therefore, there is an urgent need to understand the aberrant mechanisms driving resistance in ESCC tumors. We hypothesized that ubiquilin‐4 (UBQLN4), a...

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Bibliographic Details
Main Authors: Tomohiro Murakami, Yoshiaki Shoji, Tomohiko Nishi, Shu‐Ching Chang, Ron D. Jachimowicz, Sojun Hoshimoto, Shigeshi Ono, Yosef Shiloh, Hiroya Takeuchi, Yuko Kitagawa, Dave S. B. Hoon, Matias A. Bustos
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Molecular Oncology
Subjects:
chemoresistance
esophageal cancer
MRE11
neoadjuvant chemotherapy
ubiquilin‐4
Online Access:https://doi.org/10.1002/1878-0261.12929

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