Glucose Tolerance and Left Ventricular Pressure-Volume Relationships in Frequently Used Mouse Strains
We investigated glucose tolerance and left ventricular contractile performance in 4 frequently used mouse strains (Swiss, C57BL/6J, DBA2, and BalbC) at 24 weeks. Glucose tolerance was tested by measuring blood glucose levels in time after intraperitoneal glucose injection (2 mg/g body weight). Left...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2011-01-01
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| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/2011/281312 |
| Summary: | We investigated glucose tolerance and left ventricular contractile performance in 4 frequently used mouse strains (Swiss, C57BL/6J, DBA2, and BalbC) at 24 weeks. Glucose tolerance was tested by measuring blood glucose levels in time after intraperitoneal glucose injection (2 mg/g body weight). Left ventricular contractility was assessed by pressure-conductance analysis. Peak glucose levels and glucose area under the curve were higher (all 𝑃<.05) in C57BL/6J (418±65 mg/dL and 813±100 mg·h/dL) versus Swiss (237±66 mg/dL and 470±126 mg·h/dL), DBA2 (113±20 mg/dL and 304±49 mg·h/dL, 𝑃<.01), and BalbC mice (174±55 mg/dL and 416±70 mg·h/dL). Cardiac output was higher (all 𝑃<.05) in Swiss (14038±4530 μL/min) versus C57BL/6J (10405±2683 μL/min), DBA2 (10438±3251 μL/min), and BalbC mice (8466±3013 μL/min). Load-independent left ventricular contractility assessed as recruitable stroke work (PRSW) was comparable in all strains. In conclusion, glucose tolerance and load-dependent left ventricular performance parameters were different between 4 mice background strains, but PRSW was comparable. |
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| ISSN: | 1110-7243 1110-7251 |