Enhanced AmB Production in Streptomyces nodosus by Fermentation Regulation and Rational Combined Feeding Strategy

Enhanced AmB Production in Streptomyces nodosus by Fermentation Regulation and Rational Combined Feeding Strategy

Amphotericin B is a clinically important polyene macrolide antibiotic with a broad-spectrum antifungal activity. In this work, the addition of key precursors and differential metabolites, combined with staged fermentation process control strategies, was carried out to improve AmB production. Rationa...

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Bibliographic Details
Main Authors:	Bo Zhang, Yu-Han Zhang, Yu Chen, Kai Chen, Sheng-Xian Jiang, Kai Huang, Zhi-Qiang Liu, Yu-Guo Zheng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-07-01
Series:	Frontiers in Bioengineering and Biotechnology
Subjects:	amphotericin B differential metabolites precursors fermentation regulation combined feeding strategy
Online Access:	https://www.frontiersin.org/article/10.3389/fbioe.2020.00597/full

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