Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich’s Ataxia Neural Stem Cells

Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich’s Ataxia Neural Stem Cells

Frataxin deficiency is the pathogenic cause of Friedreich’s Ataxia, an autosomal recessive disease characterized by the increase of oxidative stress and production of free radicals in the cell. Although the onset of the pathology occurs in the second decade of life, cognitive differences and defects...

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Bibliographic Details
Main Authors: Piergiorgio La Rosa, Marta Russo, Jessica D’Amico, Sara Petrillo, Katia Aquilano, Daniele Lettieri-Barbato, Riccardo Turchi, Enrico S. Bertini, Fiorella Piemonte
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Nrf2
Friedreich’s Ataxia
neural stem cells
frataxin
neurogenesis
antioxidant
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00356/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00356/full

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