Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids

Palladium catalysed C-H functionalization ofsp3carbons typically requires the installation and subsequent removal of a temporary directing group. Here the authors report a method allowing C-H functionalization in carboxylic acids in which the carboxylate acts as a directing group.

Bibliographic Details
Main Authors:	Yan Zhu, Xiaolan Chen, Chunchen Yuan, Guobao Li, Jingyu Zhang, Yingsheng Zhao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14904

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spelling	doaj-79d36e5bbcad49988d35ee9fadc523932021-05-11T07:48:08ZengNature Publishing GroupNature Communications2041-17232017-04-01811810.1038/ncomms14904Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acidsYan Zhu0Xiaolan Chen1Chunchen Yuan2Guobao Li3Jingyu Zhang4Yingsheng Zhao5Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow UniversityKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow UniversityKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow UniversityKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow UniversityKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow UniversityKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow UniversityPalladium catalysed C-H functionalization ofsp3carbons typically requires the installation and subsequent removal of a temporary directing group. Here the authors report a method allowing C-H functionalization in carboxylic acids in which the carboxylate acts as a directing group.https://doi.org/10.1038/ncomms14904
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yan Zhu Xiaolan Chen Chunchen Yuan Guobao Li Jingyu Zhang Yingsheng Zhao
spellingShingle	Yan Zhu Xiaolan Chen Chunchen Yuan Guobao Li Jingyu Zhang Yingsheng Zhao Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids Nature Communications
author_facet	Yan Zhu Xiaolan Chen Chunchen Yuan Guobao Li Jingyu Zhang Yingsheng Zhao
author_sort	Yan Zhu
title	Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids
title_short	Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids
title_full	Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids
title_fullStr	Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids
title_full_unstemmed	Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids
title_sort	pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-04-01
description	Palladium catalysed C-H functionalization ofsp3carbons typically requires the installation and subsequent removal of a temporary directing group. Here the authors report a method allowing C-H functionalization in carboxylic acids in which the carboxylate acts as a directing group.
url	https://doi.org/10.1038/ncomms14904
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Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids

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