Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature

Macrophage activation syndrome (MAS) is a potentially fatal condition. It belongs to the hemophagocytic lymphohistiocytosis group of diseases. In adults, MAS is rarely associated with systemic lupus erythematosus, but it also arises as complication of several systemic autoimmune disorders, like anky...

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Main Authors: Guido Granata, Dario Didona, Giuseppina Stifano, Aldo Feola, Massimo Granata
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2015/294041
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spelling doaj-79c34bd25706452cbdf1b6a0242432ee2020-11-25T00:04:50ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352015-01-01201510.1155/2015/294041294041Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the LiteratureGuido Granata0Dario Didona1Giuseppina Stifano2Aldo Feola3Massimo Granata4UOC Immunologia Clinica A, Dipartimento di Medicina Clinica, Policlinico Umberto I, Sapienza Università di Roma, 00185 Roma, ItalyI Divisione Dermatologica, Istituto Dermopatico dell’Immacolata IRCCS, 00167 Roma, ItalyUOC Immunologia Clinica A, Dipartimento di Medicina Clinica, Policlinico Umberto I, Sapienza Università di Roma, 00185 Roma, ItalyUOC Immunologia Clinica A, Dipartimento di Medicina Clinica, Policlinico Umberto I, Sapienza Università di Roma, 00185 Roma, ItalyUOC Immunologia Clinica A, Dipartimento di Medicina Clinica, Policlinico Umberto I, Sapienza Università di Roma, 00185 Roma, ItalyMacrophage activation syndrome (MAS) is a potentially fatal condition. It belongs to the hemophagocytic lymphohistiocytosis group of diseases. In adults, MAS is rarely associated with systemic lupus erythematosus, but it also arises as complication of several systemic autoimmune disorders, like ankylosing spondylitis, rheumatoid arthritis, and adult-onset Still’s disease. Several treatment options for MAS have been reported in the literature, including a therapeutic regimen of etoposide, dexamethasone, and cyclosporine. Here we report a case of 42-year-old woman in whom MAS occurred as onset of systemic lupus erythematosus.http://dx.doi.org/10.1155/2015/294041
collection DOAJ
language English
format Article
sources DOAJ
author Guido Granata
Dario Didona
Giuseppina Stifano
Aldo Feola
Massimo Granata
spellingShingle Guido Granata
Dario Didona
Giuseppina Stifano
Aldo Feola
Massimo Granata
Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature
Case Reports in Medicine
author_facet Guido Granata
Dario Didona
Giuseppina Stifano
Aldo Feola
Massimo Granata
author_sort Guido Granata
title Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature
title_short Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature
title_full Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature
title_fullStr Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature
title_full_unstemmed Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature
title_sort macrophage activation syndrome as onset of systemic lupus erythematosus: a case report and a review of the literature
publisher Hindawi Limited
series Case Reports in Medicine
issn 1687-9627
1687-9635
publishDate 2015-01-01
description Macrophage activation syndrome (MAS) is a potentially fatal condition. It belongs to the hemophagocytic lymphohistiocytosis group of diseases. In adults, MAS is rarely associated with systemic lupus erythematosus, but it also arises as complication of several systemic autoimmune disorders, like ankylosing spondylitis, rheumatoid arthritis, and adult-onset Still’s disease. Several treatment options for MAS have been reported in the literature, including a therapeutic regimen of etoposide, dexamethasone, and cyclosporine. Here we report a case of 42-year-old woman in whom MAS occurred as onset of systemic lupus erythematosus.
url http://dx.doi.org/10.1155/2015/294041
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