Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation

Increased hepatic fat content (HFC) is a hallmark of non-alcoholic fatty liver (NAFL) disease, a common condition in liver transplant recipients. Proton MR spectroscopy (<sup>1</sup>H MRS) and MR imaging-based proton density fat fraction as the only diagnosis modality enable precise non-...

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Main Authors: Martin Burian, Milan Hajek, Petr Sedivy, Irena Mikova, Pavel Trunecka, Monika Dezortova
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Metabolites
Subjects:
Online Access:https://www.mdpi.com/2218-1989/11/9/625
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spelling doaj-79ba4bab7b8e49a5970047233a31a4bb2021-09-26T00:40:59ZengMDPI AGMetabolites2218-19892021-09-011162562510.3390/metabo11090625Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver TransplantationMartin Burian0Milan Hajek1Petr Sedivy2Irena Mikova3Pavel Trunecka4Monika Dezortova5MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicMR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicMR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicDepartment of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicDepartment of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicMR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicIncreased hepatic fat content (HFC) is a hallmark of non-alcoholic fatty liver (NAFL) disease, a common condition in liver transplant recipients. Proton MR spectroscopy (<sup>1</sup>H MRS) and MR imaging-based proton density fat fraction as the only diagnosis modality enable precise non-invasive measurement of HFC and, also, fatty acid profiles in vivo. Using <sup>1</sup>H MRS at 3T, we examined 47 liver transplantation candidates and 101 liver graft recipients. A point-resolved spectroscopy sequence was used to calculate the steatosis grade along with the saturated, unsaturated and polyunsaturated fractions of fatty acids in the liver. The steatosis grade measured by MRS was compared with the histological steatosis grade. HFC, represented by fat fraction values, is adept at distinguishing non-alcoholic steatohepatitis (NASH), NAFL and non-steatotic liver transplant patients. Relative hepatic lipid saturation increases while unsaturation decreases in response to increased HFC. Additionally, relative hepatic lipid saturation increases while unsaturation and polyunsaturation both decrease in liver recipients with histologically proven post-transplant NASH or NAFL compared to non-steatotic patients. HFC, measured by in vivo <sup>1</sup>H MRS, correlated well with histological results. <sup>1</sup>H MRS is a simple and fast method for in vivo analysis of HFC and its composition. It provides non-invasive support for NAFL and NASH diagnoses.https://www.mdpi.com/2218-1989/11/9/625magnetic resonanceMR spectroscopyliversteatosislipid saturationlipid profile
collection DOAJ
language English
format Article
sources DOAJ
author Martin Burian
Milan Hajek
Petr Sedivy
Irena Mikova
Pavel Trunecka
Monika Dezortova
spellingShingle Martin Burian
Milan Hajek
Petr Sedivy
Irena Mikova
Pavel Trunecka
Monika Dezortova
Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation
Metabolites
magnetic resonance
MR spectroscopy
liver
steatosis
lipid saturation
lipid profile
author_facet Martin Burian
Milan Hajek
Petr Sedivy
Irena Mikova
Pavel Trunecka
Monika Dezortova
author_sort Martin Burian
title Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation
title_short Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation
title_full Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation
title_fullStr Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation
title_full_unstemmed Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation
title_sort lipid profile and hepatic fat content measured by <sup>1</sup>h mr spectroscopy in patients before and after liver transplantation
publisher MDPI AG
series Metabolites
issn 2218-1989
publishDate 2021-09-01
description Increased hepatic fat content (HFC) is a hallmark of non-alcoholic fatty liver (NAFL) disease, a common condition in liver transplant recipients. Proton MR spectroscopy (<sup>1</sup>H MRS) and MR imaging-based proton density fat fraction as the only diagnosis modality enable precise non-invasive measurement of HFC and, also, fatty acid profiles in vivo. Using <sup>1</sup>H MRS at 3T, we examined 47 liver transplantation candidates and 101 liver graft recipients. A point-resolved spectroscopy sequence was used to calculate the steatosis grade along with the saturated, unsaturated and polyunsaturated fractions of fatty acids in the liver. The steatosis grade measured by MRS was compared with the histological steatosis grade. HFC, represented by fat fraction values, is adept at distinguishing non-alcoholic steatohepatitis (NASH), NAFL and non-steatotic liver transplant patients. Relative hepatic lipid saturation increases while unsaturation decreases in response to increased HFC. Additionally, relative hepatic lipid saturation increases while unsaturation and polyunsaturation both decrease in liver recipients with histologically proven post-transplant NASH or NAFL compared to non-steatotic patients. HFC, measured by in vivo <sup>1</sup>H MRS, correlated well with histological results. <sup>1</sup>H MRS is a simple and fast method for in vivo analysis of HFC and its composition. It provides non-invasive support for NAFL and NASH diagnoses.
topic magnetic resonance
MR spectroscopy
liver
steatosis
lipid saturation
lipid profile
url https://www.mdpi.com/2218-1989/11/9/625
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