Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation
Increased hepatic fat content (HFC) is a hallmark of non-alcoholic fatty liver (NAFL) disease, a common condition in liver transplant recipients. Proton MR spectroscopy (<sup>1</sup>H MRS) and MR imaging-based proton density fat fraction as the only diagnosis modality enable precise non-...
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doaj-79ba4bab7b8e49a5970047233a31a4bb2021-09-26T00:40:59ZengMDPI AGMetabolites2218-19892021-09-011162562510.3390/metabo11090625Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver TransplantationMartin Burian0Milan Hajek1Petr Sedivy2Irena Mikova3Pavel Trunecka4Monika Dezortova5MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicMR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicMR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicDepartment of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicDepartment of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicMR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicIncreased hepatic fat content (HFC) is a hallmark of non-alcoholic fatty liver (NAFL) disease, a common condition in liver transplant recipients. Proton MR spectroscopy (<sup>1</sup>H MRS) and MR imaging-based proton density fat fraction as the only diagnosis modality enable precise non-invasive measurement of HFC and, also, fatty acid profiles in vivo. Using <sup>1</sup>H MRS at 3T, we examined 47 liver transplantation candidates and 101 liver graft recipients. A point-resolved spectroscopy sequence was used to calculate the steatosis grade along with the saturated, unsaturated and polyunsaturated fractions of fatty acids in the liver. The steatosis grade measured by MRS was compared with the histological steatosis grade. HFC, represented by fat fraction values, is adept at distinguishing non-alcoholic steatohepatitis (NASH), NAFL and non-steatotic liver transplant patients. Relative hepatic lipid saturation increases while unsaturation decreases in response to increased HFC. Additionally, relative hepatic lipid saturation increases while unsaturation and polyunsaturation both decrease in liver recipients with histologically proven post-transplant NASH or NAFL compared to non-steatotic patients. HFC, measured by in vivo <sup>1</sup>H MRS, correlated well with histological results. <sup>1</sup>H MRS is a simple and fast method for in vivo analysis of HFC and its composition. It provides non-invasive support for NAFL and NASH diagnoses.https://www.mdpi.com/2218-1989/11/9/625magnetic resonanceMR spectroscopyliversteatosislipid saturationlipid profile |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martin Burian Milan Hajek Petr Sedivy Irena Mikova Pavel Trunecka Monika Dezortova |
spellingShingle |
Martin Burian Milan Hajek Petr Sedivy Irena Mikova Pavel Trunecka Monika Dezortova Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation Metabolites magnetic resonance MR spectroscopy liver steatosis lipid saturation lipid profile |
author_facet |
Martin Burian Milan Hajek Petr Sedivy Irena Mikova Pavel Trunecka Monika Dezortova |
author_sort |
Martin Burian |
title |
Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation |
title_short |
Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation |
title_full |
Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation |
title_fullStr |
Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation |
title_full_unstemmed |
Lipid Profile and Hepatic Fat Content Measured by <sup>1</sup>H MR Spectroscopy in Patients before and after Liver Transplantation |
title_sort |
lipid profile and hepatic fat content measured by <sup>1</sup>h mr spectroscopy in patients before and after liver transplantation |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2021-09-01 |
description |
Increased hepatic fat content (HFC) is a hallmark of non-alcoholic fatty liver (NAFL) disease, a common condition in liver transplant recipients. Proton MR spectroscopy (<sup>1</sup>H MRS) and MR imaging-based proton density fat fraction as the only diagnosis modality enable precise non-invasive measurement of HFC and, also, fatty acid profiles in vivo. Using <sup>1</sup>H MRS at 3T, we examined 47 liver transplantation candidates and 101 liver graft recipients. A point-resolved spectroscopy sequence was used to calculate the steatosis grade along with the saturated, unsaturated and polyunsaturated fractions of fatty acids in the liver. The steatosis grade measured by MRS was compared with the histological steatosis grade. HFC, represented by fat fraction values, is adept at distinguishing non-alcoholic steatohepatitis (NASH), NAFL and non-steatotic liver transplant patients. Relative hepatic lipid saturation increases while unsaturation decreases in response to increased HFC. Additionally, relative hepatic lipid saturation increases while unsaturation and polyunsaturation both decrease in liver recipients with histologically proven post-transplant NASH or NAFL compared to non-steatotic patients. HFC, measured by in vivo <sup>1</sup>H MRS, correlated well with histological results. <sup>1</sup>H MRS is a simple and fast method for in vivo analysis of HFC and its composition. It provides non-invasive support for NAFL and NASH diagnoses. |
topic |
magnetic resonance MR spectroscopy liver steatosis lipid saturation lipid profile |
url |
https://www.mdpi.com/2218-1989/11/9/625 |
work_keys_str_mv |
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