Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.

Bibliographic Details
Main Authors: Michael Tyler, Itay Tirosh
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22800-1
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spelling doaj-79b957e782e7477892adcf1d678e58392021-05-11T14:49:39ZengNature Publishing GroupNature Communications2041-17232021-05-0112111310.1038/s41467-021-22800-1Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysisMichael Tyler0Itay Tirosh1Department of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceEpithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.https://doi.org/10.1038/s41467-021-22800-1
collection DOAJ
language English
format Article
sources DOAJ
author Michael Tyler
Itay Tirosh
spellingShingle Michael Tyler
Itay Tirosh
Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
Nature Communications
author_facet Michael Tyler
Itay Tirosh
author_sort Michael Tyler
title Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_short Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_full Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_fullStr Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_full_unstemmed Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_sort decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.
url https://doi.org/10.1038/s41467-021-22800-1
work_keys_str_mv AT michaeltyler decouplingepithelialmesenchymaltransitionsfromstromalprofilesbyintegrativeexpressionanalysis
AT itaytirosh decouplingepithelialmesenchymaltransitionsfromstromalprofilesbyintegrativeexpressionanalysis
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