Refinement of Animal Model of Colorectal Carcinogenesis through the Definition of Novel Humane Endpoints

Refinement of Animal Model of Colorectal Carcinogenesis through the Definition of Novel Humane Endpoints

This study aimed to define appropriate humane endpoints (HEs) for an animal model of colorectal carcinogenesis (CRC). Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2) injected with ethylenediamine tetraacetic acid (EDTA)–saline solutions and two induced groups (CRC...

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Main Authors:	Rita Silva-Reis, Ana I. Faustino-Rocha, Mariana Gonçalves, Catarina Castro Ribeiro, Tiago Ferreira, Carla Ribeiro-Silva, Lio Gonçalves, Luís Antunes, Carlos Venâncio, Rita Ferreira, Adelina Gama, Paula A. Oliveira
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Animals
Subjects:	colorectal cancer rat welfare 1,2-dimethylhydrazine
Online Access:	https://www.mdpi.com/2076-2615/11/4/985

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