Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature

Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature

A mild and facile Cp*Rh(III)-catalyzed C–H activation and intramolecular cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines scaffolds using <i>S</i>-phenylsulfoximides and 4-diazoisochroman-3-imine as substrates under room temp...

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Bibliographic Details
Main Authors: Bao Wang, Xu Han, Jian Li, Chunpu Li, Hong Liu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
sulfoximide
C–H activation
benzothiazine
rhodium.
Online Access:https://www.mdpi.com/1420-3049/25/11/2515
Description
Summary:A mild and facile Cp*Rh(III)-catalyzed C–H activation and intramolecular cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines scaffolds using <i>S</i>-phenylsulfoximides and 4-diazoisochroman-3-imine as substrates under room temperature. This method features diverse substituents and functional groups tolerance and relatively mild reaction conditions with moderate to excellent yields. Additionally, retentive configuration of sulfoximides in the conversion has been verified.
ISSN:1420-3049

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