Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.

Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.

Camptothecin (CPT), a topoisomerase I poison, is an important drug for the treatment of solid tumors in the clinic. Nitric oxide (·NO), a physiological signaling molecule, is involved in many cellular functions, including cell proliferation, survival and death. We have previously shown that ·NO play...

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Bibliographic Details
Main Authors: Nilesh K Sharma, Ashutosh Kumar, Amrita Kumari, Erik J Tokar, Michael P Waalkes, Carl D Bortner, Jason Williams, Marilyn Ehrenshaft, Ronald P Mason, Birandra K Sinha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4635000?pdf=render

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