High-grade glioma in elderly patients: can the oncogeriatrician help?

Emeline Tabouret,1 Louis Tassy,2 Olivier Chinot,1 ElodieCrétel,3 Frederique Retornaz,4 Frederique Rousseau5 1Department of Neuro-oncology, Timone Hospital, Marseille, France; 2Department of Medical Oncology, Centre Léon Bérard, Lyon, France; 3Transveral Oncogeriatric...

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Main Authors: Tabouret E, Tassy L, Chinot O, Crétel E, Retornaz F, Rousseau F
Format: Article
Language:English
Published: Dove Medical Press 2013-12-01
Series:Clinical Interventions in Aging
Subjects:
Online Access:https://www.dovepress.com/high-grade-glioma-in-elderly-patients-can-the-oncogeriatrician-help-peer-reviewed-article-CIA
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spelling doaj-79a63ad12ea7411f99c295d6d9f550522020-11-24T21:15:24ZengDove Medical PressClinical Interventions in Aging1178-19982013-12-01Volume 81617162415196High-grade glioma in elderly patients: can the oncogeriatrician help?Tabouret ETassy LChinot OCrétel ERetornaz FRousseau FEmeline Tabouret,1 Louis Tassy,2 Olivier Chinot,1 ElodieCrétel,3 Frederique Retornaz,4 Frederique Rousseau5 1Department of Neuro-oncology, Timone Hospital, Marseille, France; 2Department of Medical Oncology, Centre Léon Bérard, Lyon, France; 3Transveral Oncogeriatric Unit, University Hospital Timone, Marseille, France; 4Departmental Gerontologic Center, Marseille, France; 5Department of Medical Oncology, Institut Paoli Calmettes, Marseille, France Abstract: Gliomas are the most frequent primary brain tumors in adults. As the population ages in Western countries, the number of people being diagnosed with glioblastoma is expected to increase. Clinical management of elderly patients with primary brain tumors is difficult, owing to multiple comorbidities, polypharmacy, decreased tolerance to chemotherapy, and an increased risk of radiation-induced neurotoxicity. A few specific randomized studies have shown a benefit for radiotherapy in elderly patients with good performance status. For patients with poor performance status, chemotherapy (temozolomide) has been shown to be associated with prolonged duration of response. Patients with methylated O6-alkylguanine deoxyribonucleic acid alkyltransferase promoter seem to have better outcomes. Oncogeriatrics proposes the geriatric evaluation of elderly patients to improve therapeutic choices and optimize the management of treatment toxicities and comorbidities. Keywords: brain tumor, older cancer patient, chemotherapy toxicity, oncogeriatric charterhttps://www.dovepress.com/high-grade-glioma-in-elderly-patients-can-the-oncogeriatrician-help-peer-reviewed-article-CIAbrain tumorolder cancer patientchemotherapy toxicityoncogeriatric charter
collection DOAJ
language English
format Article
sources DOAJ
author Tabouret E
Tassy L
Chinot O
Crétel E
Retornaz F
Rousseau F
spellingShingle Tabouret E
Tassy L
Chinot O
Crétel E
Retornaz F
Rousseau F
High-grade glioma in elderly patients: can the oncogeriatrician help?
Clinical Interventions in Aging
brain tumor
older cancer patient
chemotherapy toxicity
oncogeriatric charter
author_facet Tabouret E
Tassy L
Chinot O
Crétel E
Retornaz F
Rousseau F
author_sort Tabouret E
title High-grade glioma in elderly patients: can the oncogeriatrician help?
title_short High-grade glioma in elderly patients: can the oncogeriatrician help?
title_full High-grade glioma in elderly patients: can the oncogeriatrician help?
title_fullStr High-grade glioma in elderly patients: can the oncogeriatrician help?
title_full_unstemmed High-grade glioma in elderly patients: can the oncogeriatrician help?
title_sort high-grade glioma in elderly patients: can the oncogeriatrician help?
publisher Dove Medical Press
series Clinical Interventions in Aging
issn 1178-1998
publishDate 2013-12-01
description Emeline Tabouret,1 Louis Tassy,2 Olivier Chinot,1 ElodieCrétel,3 Frederique Retornaz,4 Frederique Rousseau5 1Department of Neuro-oncology, Timone Hospital, Marseille, France; 2Department of Medical Oncology, Centre Léon Bérard, Lyon, France; 3Transveral Oncogeriatric Unit, University Hospital Timone, Marseille, France; 4Departmental Gerontologic Center, Marseille, France; 5Department of Medical Oncology, Institut Paoli Calmettes, Marseille, France Abstract: Gliomas are the most frequent primary brain tumors in adults. As the population ages in Western countries, the number of people being diagnosed with glioblastoma is expected to increase. Clinical management of elderly patients with primary brain tumors is difficult, owing to multiple comorbidities, polypharmacy, decreased tolerance to chemotherapy, and an increased risk of radiation-induced neurotoxicity. A few specific randomized studies have shown a benefit for radiotherapy in elderly patients with good performance status. For patients with poor performance status, chemotherapy (temozolomide) has been shown to be associated with prolonged duration of response. Patients with methylated O6-alkylguanine deoxyribonucleic acid alkyltransferase promoter seem to have better outcomes. Oncogeriatrics proposes the geriatric evaluation of elderly patients to improve therapeutic choices and optimize the management of treatment toxicities and comorbidities. Keywords: brain tumor, older cancer patient, chemotherapy toxicity, oncogeriatric charter
topic brain tumor
older cancer patient
chemotherapy toxicity
oncogeriatric charter
url https://www.dovepress.com/high-grade-glioma-in-elderly-patients-can-the-oncogeriatrician-help-peer-reviewed-article-CIA
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