Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

<p>Abstract</p> <p>Background</p> <p>Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result in the commonest type of maturity onset diabetes of the young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to...

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Bibliographic Details
Main Authors: Bacon Siobhan, Kyithar Ma, Schmid Jasmin, Rizvi Syed R, Bonner Caroline, Graf Rolf, Prehn Jochen HM, Byrne Maria M
Format: Article
Language:English
Published: BMC 2012-07-01
Series:BMC Endocrine Disorders
Subjects:
Maturity onset diabetes of the young (MODY)
Apoptosis
Serum biomarker
Beta-Cell
Type 1 diabetes
Pancreatic stone protein (PSP)
Regenerating gene 1A (reg1A)
Online Access:http://www.biomedcentral.com/1472-6823/12/13

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