The potential of panHER inhibition in cancer

The potential of panHER inhibition in cancer

Purpose: Hyper activation of the HER (erbB) family receptors, HER 1-4, leads to up-regulation of the three vital signalling pathways: mitogen activated protein kinase, phosphoinositide 3-kinase/ AKT, and Janus kinase/ signal transducer and activator of transcription pathways. Blocking HER1/EGFR has...

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Bibliographic Details
Main Authors: Xiaochun eWang, Kathleen eBatty, Philip eCrowe, David eGoldstein, Jia-Lin eYang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Oncology
Subjects:
Drug Resistance
EGFR
targeted therapy
PanHER inhibitors
HER signalling pathways
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00002/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00002/full

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