Clinical effect of Mongolian drug Qinggan Jiuwei powder in treatment of alcoholic hepatitis

• Main Authors: GE Hongyan, ZHAO Baisui, ZHANG Shihua
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2016-10-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=7752
• ISSN: 1001-5256; 1001-5256

Objective To investigate the clinical effect of Mongolian drug Qinggan Jiuwei powder in the treatment of patients with alcoholic hepatitis. Methods A total of 63 patients with alcoholic hepatitis who were admitted to Affiliated Hospital of Inner Mongolia University for The Nationalities from May 2014 to April 2016 were enrolled. The 32 patients in the trial group were given Mongolian drug Qinggan Jiuwei powder, and the 31 patients in the control group were given reduced glutathione tablets. The course of treatment was 4 weeks for both groups, and the patients were asked to quit drinking, stay in bed, and have a rest. The t-test was used for the comparison of continuous data between groups. Results After treatment, the control group showed significant improvements in the liver function parameters alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) (ALT: 38.7±13.3 U/L vs 77.5±16.7 U/L, t=10.21, P＜0.01; AST: 43.8±21.8 U/L vs 176.6±40.1 U/L, t=16.90, P＜0.01; GGT: 63.8±21.7 U/L vs 302.9±73.3 U/L, t=17.40, P＜0.01); the trial group also showed significant improvements in these parameters (ALT: 37.6±14.6 U/L vs 78.1±17.5 U/L, t=10.10, P＜0.01; AST: 39.6±15.3 U/L vs 180.3±44.3 U/L, t=16.40, P＜0.01; GGT: 59.9±23.8 U/L vs 304.7±66.5 U/L, t=19.60, P＜0.01). After treatment, the control group showed significant improvements in the serum liver fibrosis parameters hyaluronic acid, precollagen type Ⅲ, laminin, and collagen type Ⅳ(hyaluronic acid: 122.1±36.2 ng/ml vs 369.2±139.8 ng/ml, t=9.52, P＜0.05; precollagen type Ⅲ: 118.6±43.8 ng/ml vs 185.9±92.7 ng/ml, t=3.66, P＜0.05; laminin: 137.2±49.9 ng/ml vs 166.1±50.4 ng/ml, t=2.24, P＜0.05; collagen type Ⅳ: 128.7±48.3 ng/ml vs 155.1±44.5 ng/ml, t=2.27, P＜0.05); the trial group also showed significant improvements in these parameters (hyaluronic acid: 101.1±27.9 ng/ml vs 367.4±149.7 ng/ml, t=9.88, P＜0.01; precollagen type Ⅲ: 91.6±48.4 ng/ml vs 188.3±100.5 ng/ml, t=4.95, P＜0.01; laminin: 94.8±34.6 ng/ml vs 167.6±48.7 ng/ml, t=5.61, P＜0.01; collagen type Ⅳ: 92.7±30.3 ng/ml vs 161.3±62.2 ng/ml, t=6.87, P＜0.01). There were significant differences in the liver function parameters after treatment between the two groups (t=2.53, 2.31, 3.56, and 3.90, all P＜0.05). Conclusion The Mongolian drug Qinggan Jiuwei powder can improve liver function and reduce liver fibrosis parameters in patients with alcoholic hepatitis.