CTCF mediates the cell-type specific spatial organization of the Kcnq5 locus and the local gene regulation.

CTCF mediates the cell-type specific spatial organization of the Kcnq5 locus and the local gene regulation.

Chromatin loops play important roles in the dynamic spatial organization of genes in the nucleus. Growing evidence has revealed that the multivalent functional zinc finger protein CCCTC-binding factor (CTCF) is a master regulator of genome spatial organization, and mediates the ubiquitous chromatin...

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Bibliographic Details
Main Authors: Licheng Ren, Yang Wang, Minglei Shi, Xiaoning Wang, Zhong Yang, Zhihu Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3275579?pdf=render

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