Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result i...
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Bibliographic Details
| Main Authors: |
Seiji Ishii,
Masaaki Torii,
Alexander I. Son,
Meenu Rajendraprasad,
Yury M. Morozov,
Yuka Imamura Kawasawa,
Anna C. Salzberg,
Mitsuaki Fujimoto,
Kristen Brennand,
Akira Nakai,
Valerie Mezger,
Fred H. Gage,
Pasko Rakic,
Kazue Hashimoto-Torii |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15157
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