Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats

Puerarin is an isoflavone isolated from Radix puerariae. Emerging evidence shown that puerarin possesses therapeutic benefits that aid in the prevention of cardiovascular diseases. In this study, we evaluated the effects of puerarin on oxidative stress and cardiac fibrosis induced by abdominal aorti...

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Bibliographic Details
Main Authors: Shao-Ai Cai, Ning Hou, Gan-Jian Zhao, Xia-Wen Liu, Ying-Yan He, Hai-Lin Liu, Yong-Quan Hua, Li-Rong Li, Yin Huang, Cai-Wen Ou, Cheng-Feng Luo, Min-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
puerarin
cardiac fibrosis
Nrf2
UGT1A1
metabolic feedback loop
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00540/full

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