Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage

Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage

Recurrent liver cancer after surgery is often treated with radiotherapy, which induces liver damage. It has been documented that activation of the TGF-β and NF-κB signaling pathways plays important roles in irradiation-induced liver pathologies. However, the significance of mTOR signaling remains un...

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Bibliographic Details
Main Authors: Wuping Yang, Lijian Shao, Sihong Zhu, Huan Li, Xinxin Zhang, Congcong Ding, Xincheng Wu, Rui Xu, Mengzhen Yue, Jiahui Tang, Bohai Kuang, Guangqin Fan, Qingxian Zhu, Huihong Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
irradiation
liver damage
mTORC1
rapamycin
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00228/full

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