Targeting senescent cell clearance: An approach to delay aging and age-associated disorders

Targeting senescent cell clearance: An approach to delay aging and age-associated disorders

Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases and aging itself. Therefore, the targeted elimination of senescent cells may be beneficial for long...

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Bibliographic Details
Main Authors: Zhengqi Qiu, Jiali Jia, Haoman Zou, Ying Ao, Baohua Liu, Zimei Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-01-01
Series:Translational Medicine of Aging
Subjects:
Senescent cells
Senolytic drugs
SASP
Aging
Cellular immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2468501120300286

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