Docetaxel-loaded solid lipid nanoparticles prevent tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells

Docetaxel-loaded solid lipid nanoparticles prevent tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells

Abstract Background Metastasis causes the most breast cancer-related deaths in women. Here, we investigated the antitumor effect of solid lipid nanoparticles (SLN-DTX) when used in the treatment of metastatic breast tumors using 4T1-bearing BALB/c mice. Results Solid lipid nanoparticles (SLNs) were...

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Bibliographic Details
Main Authors: Márcia Cristina Oliveira da Rocha, Patrícia Bento da Silva, Marina Arantes Radicchi, Bárbara Yasmin Garcia Andrade, Jaqueline Vaz de Oliveira, Tom Venus, Carolin Merker, Irina Estrela-Lopis, João Paulo Figueiró Longo, Sônia Nair Báo
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Nanobiotechnology
Subjects:
Cellular uptake
4T1
NIH-3T3
IL-6
BCL-2
Ki-67 and antitumor effect
Online Access:http://link.springer.com/article/10.1186/s12951-020-00604-7

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