Methods to Evaluate Skin Penetration In Vitro

Methods to Evaluate Skin Penetration In Vitro

Dermal and transdermal drug therapy is increasing in importance nowadays in drug development. To completely utilize the potential of this administration route, it is necessary to optimize the drug release and skin penetration measurements. This review covers the most well-known and up-to-date method...

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Main Authors: Stella Zsikó, Erzsébet Csányi, Anita Kovács, Mária Budai-Szűcs, Attila Gácsi, Szilvia Berkó
Format: Article
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2019-08-01
Series:Scientia Pharmaceutica
Subjects:
drug release
skin penetration
Franz cell
skin-PAMPA
tape stripping
two-photon microscopy
CLSM
confocal Raman microscopy
Online Access:https://www.mdpi.com/2218-0532/87/3/19
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spelling doaj-79575afd631944e2a86a8992b7e75d282020-11-25T02:30:14ZengÖsterreichische Apotheker-Verlagsgesellschaft m. b. H.Scientia Pharmaceutica2218-05322019-08-018731910.3390/scipharm87030019scipharm87030019Methods to Evaluate Skin Penetration In VitroStella Zsikó0Erzsébet Csányi1Anita Kovács2Mária Budai-Szűcs3Attila Gácsi4Szilvia Berkó5Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryDermal and transdermal drug therapy is increasing in importance nowadays in drug development. To completely utilize the potential of this administration route, it is necessary to optimize the drug release and skin penetration measurements. This review covers the most well-known and up-to-date methods for evaluating the cutaneous penetration of drugs in vitro as a supporting tool for pharmaceutical research scientists in the early stage of drug development. The aim of this article is to present various experimental models used in dermal/transdermal research and summarize the novel knowledge about the main in vitro methods available to study skin penetration. These techniques are: Diffusion cell, skin-PAMPA, tape stripping, two-photon microscopy, confocal laser scanning microscopy, and confocal Raman microscopic method.https://www.mdpi.com/2218-0532/87/3/19drug releaseskin penetrationFranz cellskin-PAMPAtape strippingtwo-photon microscopyCLSMconfocal Raman microscopy
collection DOAJ
language English
format Article
sources DOAJ
author Stella Zsikó
Erzsébet Csányi
Anita Kovács
Mária Budai-Szűcs
Attila Gácsi
Szilvia Berkó
spellingShingle Stella Zsikó
Erzsébet Csányi
Anita Kovács
Mária Budai-Szűcs
Attila Gácsi
Szilvia Berkó
Methods to Evaluate Skin Penetration In Vitro
Scientia Pharmaceutica
drug release
skin penetration
Franz cell
skin-PAMPA
tape stripping
two-photon microscopy
CLSM
confocal Raman microscopy
author_facet Stella Zsikó
Erzsébet Csányi
Anita Kovács
Mária Budai-Szűcs
Attila Gácsi
Szilvia Berkó
author_sort Stella Zsikó
title Methods to Evaluate Skin Penetration In Vitro
title_short Methods to Evaluate Skin Penetration In Vitro
title_full Methods to Evaluate Skin Penetration In Vitro
title_fullStr Methods to Evaluate Skin Penetration In Vitro
title_full_unstemmed Methods to Evaluate Skin Penetration In Vitro
title_sort methods to evaluate skin penetration in vitro
publisher Österreichische Apotheker-Verlagsgesellschaft m. b. H.
series Scientia Pharmaceutica
issn 2218-0532
publishDate 2019-08-01
description Dermal and transdermal drug therapy is increasing in importance nowadays in drug development. To completely utilize the potential of this administration route, it is necessary to optimize the drug release and skin penetration measurements. This review covers the most well-known and up-to-date methods for evaluating the cutaneous penetration of drugs in vitro as a supporting tool for pharmaceutical research scientists in the early stage of drug development. The aim of this article is to present various experimental models used in dermal/transdermal research and summarize the novel knowledge about the main in vitro methods available to study skin penetration. These techniques are: Diffusion cell, skin-PAMPA, tape stripping, two-photon microscopy, confocal laser scanning microscopy, and confocal Raman microscopic method.
topic drug release
skin penetration
Franz cell
skin-PAMPA
tape stripping
two-photon microscopy
CLSM
confocal Raman microscopy
url https://www.mdpi.com/2218-0532/87/3/19
work_keys_str_mv AT stellazsiko methodstoevaluateskinpenetrationinvitro
AT erzsebetcsanyi methodstoevaluateskinpenetrationinvitro
AT anitakovacs methodstoevaluateskinpenetrationinvitro
AT mariabudaiszucs methodstoevaluateskinpenetrationinvitro
AT attilagacsi methodstoevaluateskinpenetrationinvitro
AT szilviaberko methodstoevaluateskinpenetrationinvitro
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