Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

Abstract Background Tibial fracture is associated with inflammatory reaction leading to severe pain syndrome. Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain. Methods This study aims at defining the role of B1 and B2-kinin recept...

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Bibliographic Details
Main Authors: Vincent Minville, Lionel Mouledous, Acil Jaafar, Réjean Couture, Anne Brouchet, Bernard Frances, Ivan Tack, Jean-Pierre Girolami
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Translational Medicine
Subjects:
Pain
Bradykinin
B1 receptor
B2 receptor
Fracture
Orthopedic
Online Access:http://link.springer.com/article/10.1186/s12967-019-2095-9

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