Nonlinear Mixed-Effect Pharmacokinetic Modeling and Distribution of Doxycycline in Healthy Female Donkeys after Multiple Intragastric Dosing–Preliminary Investigation

Nonlinear Mixed-Effect Pharmacokinetic Modeling and Distribution of Doxycycline in Healthy Female Donkeys after Multiple Intragastric Dosing–Preliminary Investigation

Doxycycline (DXC) is a broad-spectrum antibacterial antimicrobial administered to horses for the treatment of bacterial infections which may also affect donkeys. Donkeys have a different metabolism than horses, leading to differences in the pharmacokinetics of drugs compared to horses. This study ai...

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Bibliographic Details
Main Authors: Ronan J. J. Chapuis, Joe S. Smith, Hilari M. French, Felix Ngosa Toka, Erik W. Peterson, Erika L. Little
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Animals
Subjects:
doxycycline hyclate
intragastric
donkey
pharmacokinetics
serum
synovial fluid
Online Access:https://www.mdpi.com/2076-2615/11/7/2047

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