Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated primary human hepatocytes, HepG2 cells, and Rhes...

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Bibliographic Details
Main Authors: Hong Li, Jing Shen, Tong Wu, Jiangying Kuang, Qinhui Liu, Shihai Cheng, Shiyun Pu, Lei Chen, Rui Li, Yanping Li, Min Zou, Zhiyong Zhang, Wei Jiang, Aijuan Qu, Jinhan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
FNDC5/Irisin
FXR
hyperlipidemia
atherosclerosis
ApoE-/-
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00548/full

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