Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation

Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation

Caffeine (1,3,7-trimethylxanthine) is a xanthine alkaloid found in a number of dietary products consumed worldwide, such as coffee, tea, and soft beverages, and is known to act as a modifying agent for cytotoxic chemotherapeutic drugs. Studies have shown that caffeine reduces the cytotoxic effects o...

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Bibliographic Details
Main Authors: Huanhuan Xu, Litian Wang, Boya Shi, Lihong Hu, Chunxia Gan, Ya Wang, Zemin Xiang, Xuanjun Wang, Jun Sheng
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Caffeine
Paclitaxel
Anticancer activity
α-tubulin acetylation
Tumor growth
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030634X

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