Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA

Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA

Abstract Background Osteoarthritis (OA) is a major cause of limb dysfunction, and distraction arthroplasty which generates intermittent hydrostatic pressure (IHP) is an effective approach for OA treatment. However, the result was not always satisfactory and the reasons remained unresolved. Because a...

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Bibliographic Details
Main Authors: Hanhao Dai, Ran Chen, Chang Gui, Tianqi Tao, Yingbin Ge, Xilian Zhao, Ran Qin, Wangxiang Yao, Song Gu, Yiqiu Jiang, Jianchao Gui
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Stem Cell Research & Therapy
Subjects:
Senescence
Cartilage
Stem cell
Osteoarthritis
Senolytics
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13287-020-01708-5

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