An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients

An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to disease susceptibility in humans, with the most responsible locus being the major histocompatibility complex (MHC). Certain MHC alleles...

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Bibliographic Details
Main Authors:	Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2016/7959060

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