Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation

Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation

Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and play an integrative role in pain processing and inflammatory functions. Lipid rafts are liquid-ordered plasma membrane microdomains rich in cholesterol, sph...

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Main Authors: Ádám Horváth, Tünde Biró-Sütő, Boglárka Kántás, Maja Payrits, Rita Skoda-Földes, Eszter Szánti-Pintér, Zsuzsanna Helyes, Éva Szőke
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
inflammation
lipid rafts
methyl β-cyclodextrin
nerve terminal
pain
sensory neuron
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.559109/full

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