Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells

Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells

CD4+CD25+Foxp3+ regulatory T cells (Tregs) accumulate in bone marrow microenvironment in acute myeloid leukemia (AML). However, little is known about how the tumor environment including tumor cells themselves affects this process. Here we demonstrated that AML cells expressed inducible T-cell costim...

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Bibliographic Details
Main Authors: Yixiang Han, Yuqing Dong, Qianqian Yang, Wanling Xu, Songfu Jiang, Zhijie Yu, Kang Yu, Shenghui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
regulatory T cells
inducible T-cell costimulator ligand
inducible T-cell costimulator
interleukin-10
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02227/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02227/full

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