Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine

TASK-3 potassium (K<sup>+</sup>) channels are highly expressed in the central nervous system, regulating the membrane potential of excitable cells. TASK-3 is involved in neurotransmitter action and has been identified as an oncogenic K<sup>+</sup> channel. For this reason, th...

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Bibliographic Details
Main Authors:	David Ramírez, Mauricio Bedoya, Aytug K. Kiper, Susanne Rinné, Samuel Morales-Navarro, Erix W. Hernández-Rodríguez, Francisco V. Sepúlveda, Niels Decher, Wendy González
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	International Journal of Molecular Sciences
Subjects:	TASK-3 channel 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine derivatives PK-THPP TASK channels blockers mutagenesis screen molecular docking molecular dynamics drug-protein interaction
Online Access:	https://www.mdpi.com/1422-0067/20/9/2252

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