Switching the activity of Cas12a using guide RNA strand displacement circuits

Switching the activity of Cas12a using guide RNA strand displacement circuits

Cas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates.

Bibliographic Details
Main Authors: Lukas Oesinghaus, Friedrich C. Simmel
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09953-w
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spelling doaj-79110551716e4defa6c6b1044bdfa7e02021-05-11T12:15:56ZengNature Publishing GroupNature Communications2041-17232019-05-0110111110.1038/s41467-019-09953-wSwitching the activity of Cas12a using guide RNA strand displacement circuitsLukas Oesinghaus0Friedrich C. Simmel1Physics Department E14, Technical University MunichPhysics Department E14, Technical University MunichCas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates.https://doi.org/10.1038/s41467-019-09953-w
collection DOAJ
language English
format Article
sources DOAJ
author Lukas Oesinghaus
Friedrich C. Simmel
spellingShingle Lukas Oesinghaus
Friedrich C. Simmel
Switching the activity of Cas12a using guide RNA strand displacement circuits
Nature Communications
author_facet Lukas Oesinghaus
Friedrich C. Simmel
author_sort Lukas Oesinghaus
title Switching the activity of Cas12a using guide RNA strand displacement circuits
title_short Switching the activity of Cas12a using guide RNA strand displacement circuits
title_full Switching the activity of Cas12a using guide RNA strand displacement circuits
title_fullStr Switching the activity of Cas12a using guide RNA strand displacement circuits
title_full_unstemmed Switching the activity of Cas12a using guide RNA strand displacement circuits
title_sort switching the activity of cas12a using guide rna strand displacement circuits
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-05-01
description Cas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates.
url https://doi.org/10.1038/s41467-019-09953-w
work_keys_str_mv AT lukasoesinghaus switchingtheactivityofcas12ausingguidernastranddisplacementcircuits
AT friedrichcsimmel switchingtheactivityofcas12ausingguidernastranddisplacementcircuits
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