Switching the activity of Cas12a using guide RNA strand displacement circuits
Cas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates.
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09953-w |
| Summary: | Cas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates. |
|---|---|
| ISSN: | 2041-1723 |