Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells.

Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells.

To date, malignant pheochromocytomas and paragangliomas (PHEOs/PGLs) cannot be effectively cured and thus novel treatment strategies are urgently needed. Lovastatin has been shown to effectively induce apoptosis in mouse PHEO cells (MPC) and the more aggressive mouse tumor tissue-derived cells (MTT)...

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Main Authors: Stephanie M J Fliedner, Tobias Engel, Nikoletta K Lendvai, Uma Shankavaram, Svenja Nölting, Robert Wesley, Abdel G Elkahloun, Hendrik Ungefroren, Angela Oldoerp, Gary Lampert, Hendrik Lehnert, Henri Timmers, Karel Pacak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4028222?pdf=render

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