The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism

The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism

Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2′ site) upstream of the fusion peptide in the spike protein, which plays roles in virion adsorption and fusion. Mutation of the S2′ site of QX genotype (QX-type) infectious bronchitis virus (IBV) spike p...

Full description

Bibliographic Details
Main Authors: Jinlong Cheng, Ye Zhao, Gang Xu, Keran Zhang, Wenfeng Jia, Yali Sun, Jing Zhao, Jia Xue, Yanxin Hu, Guozhong Zhang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Viruses
Subjects:
coronavirus
infectious bronchitis virus
qx type
furin-s2′ site
encephalitis
neurotropism
Online Access:https://www.mdpi.com/1999-4915/11/10/972

Internet

https://www.mdpi.com/1999-4915/11/10/972

Similar Items