Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.

Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.

The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA) neuron degeneration in the SN. Here, we show that...

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Bibliographic Details
Main Authors: Liviu Aron, Pontus Klein, Thu-Trang Pham, Edgar R Kramer, Wolfgang Wurst, Rüdiger Klein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2850379?pdf=render

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