Synthesis and antiproliferative activity of 4H-chromonephenylhydrazones, 1H-pyrazolecarboxylates and pyrazolylmethanones

• Main Authors: China Raju Bhimapaka, Nageswara Rao Rayala, Rajkumar Kommera, Dayakar Cherupally, Ramalinga Murthy Thampunuri, V Kalivendi Shasi
• Format: Article
• Language: English
• Published: Slovenian Chemical Society 2018-03-01
• Series: Acta Chimica Slovenica
• Subjects: 3-Formylchromones; 1H-pyrazolecarboxylates; 1H-pyrazolylmethanones; cycloaddition and antiproliferative activity
• Online Access: https://journals.matheo.si/index.php/ACSi/article/view/3453

Series of 4H-chromone-based hydrazones 3a–z, pyrazolecarboxylates 5a–x and pyrazolylmethanones 6a–u were prepared and screened for their anti-proliferative activity on A549, HeLa, DU145 and MDAMB 231 cell lines. The hydrazone compound 3s with a chloro substituent on the chromanone moiety and a methoxy group on the phenyl ring displayed promising activity on A549, HeLa and DU145 cell lines. The compound 5p with a bromo substituent on the chromanone moiety and a methyl group on the phenyl ring displayed potent activity on DU145. Furopyrazolecarboxylate 5w having a methyl substituent on the phenyl ring displayed potent activity on HeLa cell line. The pyrazolylmethanone 6e with a fluoro substituent on the phenyl ring and compound 6j having a methyl substituent on the chromanone moiety and a methoxy group on the phenyl ring have shown promising anti-proliferative activity on HeLa cell line.