Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma

Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma

Abstract Background The third-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients with non-small cell lung carcinoma (NSCLC) who carry active EGFR mutations, as well as those who have developed acquired resistance...

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Bibliographic Details
Main Authors: Yuting Meng, Xixi Qian, Li Zhao, Nan Li, Shengjie Wu, Baoan Chen, Tong Sun, Xuerong Wang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cancer Cell International
Subjects:
Lung cancer
EGFR
Bromodomain and extra-terminal protein
Histone deacetylase
Online Access:https://doi.org/10.1186/s12935-021-01914-y

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