Effect of EPA on Hsp90 and GRα protein expression in multiple myeloma drug-resistant cells

Effect of EPA on Hsp90 and GRα protein expression in multiple myeloma drug-resistant cells

Abstract Background Approximately 20% of MM patients harbor glucocorticoid (GC) resistance and are not responsive to therapeutic effect. Chaperoneheat-shock proteins Hsp90 is needed for ligand docking, The imbalance of Hsp90/GRα (glucocorticoid receptor α) may be an important cause of GC resistance....

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Bibliographic Details
Main Authors: Shenghao Wu, Yuemiao Chen, Xueshuang Wang, Shanshan Weng, Wenjin Zhou, Zhen Liu
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Cancer
Subjects:
Myeloma
EPA
Heat shock protein-90
GRα
Apoptosis
Online Access:https://doi.org/10.1186/s12885-021-08804-6

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