Bayesian analysis of Glucose dynamics during the Oral Glucose Tolerance Test (OGTT)

Bayesian analysis of Glucose dynamics during the Oral Glucose Tolerance Test (OGTT)

This paper proposes a model that considers the action and timing of insulin and glucagon in glucose homeostasis after an oral stimulus. We use the Bayesian paradigm to infer kinetic rates, namely insulin and glucagon secretion, gastrointestinal emptying, and basal glucose concentration in blood. We...

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Bibliographic Details
Main Authors: Hugo Flores-Arguedas, Marcos A. Capistrán
Format: Article
Language:English
Published: AIMS Press 2021-05-01
Series:Mathematical Biosciences and Engineering
Subjects:
ogtt
bayesian inference
type 2 diabetes
glucose dynamics
dynamical systems
Online Access:http://www.aimspress.com/article/doi/10.3934/mbe.2021235?viewType=HTML
Description
Summary:This paper proposes a model that considers the action and timing of insulin and glucagon in glucose homeostasis after an oral stimulus. We use the Bayesian paradigm to infer kinetic rates, namely insulin and glucagon secretion, gastrointestinal emptying, and basal glucose concentration in blood. We identify two insulin scores related to glucose concentration in both blood and the gastrointestinal tract. The scores allow us to suggest a classification for individuals with impaired insulin sensitivity.
ISSN:1551-0018

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