Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

Chromatin moves with subdiffusive and spatially constrained dynamics within the cell nucleus. Here, we use single-locus tracking by time-lapse fluorescence microscopy to uncover information regarding the forces that influence chromatin movement following the induction of a persistent DNA double-stra...

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Bibliographic Details
Main Authors: Assaf Amitai, Andrew Seeber, Susan M. Gasser, David Holcman
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
chromatin dynamics
nucleosome compaction
polymer model
double-strand break
actin cytoskeleton
microtubules
time-lapse imaging
DNA damage
DNA mobility
numerical stimulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300542

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