Cyproterone acetate acts as a disruptor of the aryl hydrocarbon receptor

Abstract Prostate cancer is a major cause of death in males. Cyproterone acetate (CPA), the steroidal anti-androgen for part of androgen deprivation therapy, may block the androgen-receptor interaction and then reduce serum testosterone through its weak anti-gonadotropic action. In addition to CPA i...

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Bibliographic Details
Main Authors: Chih-Shou Chen, Guan-Lun Gao, Dong-Ru Ho, Chih-Yi Lin, Yu-Ting Chou, Shan-Chun Chen, Min-Cong Huang, Wen-Ya Kao, Jyan-Gwo Joseph Su
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84769-7