Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia...

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Main Authors:	Zijing Guo, Zhidong Zhang, Meera Prajapati, Yanmin Li
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Viruses
Subjects:	lymphopenia viruses apoptosis cytokines immune response
Online Access:	https://www.mdpi.com/1999-4915/13/9/1876

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spelling	doaj-78ad01fd163e406a85a53fbe65d2a8a72021-09-26T01:37:55ZengMDPI AGViruses1999-49152021-09-01131876187610.3390/v13091876Lymphopenia Caused by Virus Infections and the Mechanisms BeyondZijing Guo0Zhidong Zhang1Meera Prajapati2Yanmin Li3State Key Laboratory on Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, ChinaCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, ChinaCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, ChinaCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, ChinaViral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed.https://www.mdpi.com/1999-4915/13/9/1876lymphopeniavirusesapoptosiscytokinesimmune response
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zijing Guo Zhidong Zhang Meera Prajapati Yanmin Li
spellingShingle	Zijing Guo Zhidong Zhang Meera Prajapati Yanmin Li Lymphopenia Caused by Virus Infections and the Mechanisms Beyond Viruses lymphopenia viruses apoptosis cytokines immune response
author_facet	Zijing Guo Zhidong Zhang Meera Prajapati Yanmin Li
author_sort	Zijing Guo
title	Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_short	Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_full	Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_fullStr	Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_full_unstemmed	Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_sort	lymphopenia caused by virus infections and the mechanisms beyond
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2021-09-01
description	Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed.
topic	lymphopenia viruses apoptosis cytokines immune response
url	https://www.mdpi.com/1999-4915/13/9/1876
work_keys_str_mv	AT zijingguo lymphopeniacausedbyvirusinfectionsandthemechanismsbeyond AT zhidongzhang lymphopeniacausedbyvirusinfectionsandthemechanismsbeyond AT meeraprajapati lymphopeniacausedbyvirusinfectionsandthemechanismsbeyond AT yanminli lymphopeniacausedbyvirusinfectionsandthemechanismsbeyond
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Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

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