P2X4 receptor–eNOS signaling pathway in cardiac myocytes as a novel protective mechanism in heart failure

We have demonstrated using immunoprecipitation and immunostaining a novel physical association of the P2X4 receptor (P2X4R), a ligand-gated ion channel, with the cardioprotective, calcium-dependent enzyme endothelial nitric oxide synthase (eNOS). Treatment of murine ventricular myocytes with the P2X...

Full description

Bibliographic Details
Main Authors: Ronghua Yang, Dardan Beqiri, Jian-Bing Shen, John M. Redden, Kimberly Dodge-Kafka, Kenneth A. Jacobson, Bruce T. Liang
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014000439