Atractylenolide I Induces Apoptosis and Suppresses Glycolysis by Blocking the JAK2/STAT3 Signaling Pathway in Colorectal Cancer Cells

Atractylenolide I Induces Apoptosis and Suppresses Glycolysis by Blocking the JAK2/STAT3 Signaling Pathway in Colorectal Cancer Cells

Colorectal cancer (CRC) is the third most common cancer worldwide and is associated with a poor clinical outcome and survival. Therefore, the development of novel therapeutic agents for CRC is imperative. Atractylenolide I (AT-I) is a sesquiterpenoid lactone derivative of Rhizoma Atractylodis macroc...

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Bibliographic Details
Main Authors: Yanxi Li, Yongpeng Wang, Zhexian Liu, Xingqi Guo, Ziwei Miao, Siping Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
atractylenolide I
colorectal cancer
apoptosis
glycolysis
JAK2
STAT3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00273/full

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