A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.

A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.

CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different H...

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Main Authors: Supranee Buranapraditkun, Ursula Hempel, Patrawadee Pitakpolrat, Rachel L Allgaier, Pattarawat Thantivorasit, Sven-Iver Lorenzen, Sunee Sirivichayakul, William H Hildebrand, Marcus Altfeld, Christian Brander, Bruce D Walker, Praphan Phanuphak, Pokrath Hansasuta, Sarah L Rowland-Jones, Todd M Allen, Kiat Ruxrungtham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3161737?pdf=render

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